Reactome: A Curated Pathway Database

Highly sodium permeable acetylcholine nicotinic receptors

Stable Identifier
R-HSA-629587
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Nicotinic acetylcholne receptors that have low Ca2+ permeability allow the influx of Na+ which causes depolarization of the membrane initiating voltage dependent responses such as activation of voltage dependent opening of Ca2+ channels and thus eliciting an increase in Ca2+ and downstream signaling. These receptors could be found in both presynaptic and postsynaptic terminals.

Literature References
PubMed ID Title Journal Year
9110108 Nicotine and sympathetic neurotransmission Cardiovasc Drugs Ther 1997
Participants
Participant Of
Orthologous Events