Reactome: A Curated Pathway Database

Highly sodium permeable acetylcholine nicotinic receptors (R-HSA-629587)

Species Homo sapiens


Nicotinic acetylcholne receptors that have low Ca2+ permeability allow the influx of Na+ which causes depolarization of the membrane initiating voltage dependent responses such as activation of voltage dependent opening of Ca2+ channels and thus eliciting an increase in Ca2+ and downstream signaling. These receptors could be found in both presynaptic and postsynaptic terminals.

Locations in the PathwayBrowser
Additional Information
Compartment cytosol , extracellular region , plasma membrane
Literature References
pubMedId Title Journal Year
9110108 Nicotine and sympathetic neurotransmission Cardiovasc Drugs Ther 1997