Reactome: A Curated Pathway Database

TNF(1-233) (R-HSA-66220)

Species Homo sapiens

Locations in the PathwayBrowser
Immune System(Homo sapiens)

Signal Transduction(Homo sapiens)

Other forms of this molecule

Additional Information
External reference name TNF
External reference id P01375
Synonyms TNF-alpha, Tumor necrosis factor precursor (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (Cachectin), Tumor necrosis factor precursor, Tumor necrosis factor ligand superfamily member 2, TNF-a
Compartment plasma membrane
Other Identifiers 0002450619, 11721577_at, 1852_at, 1A8M, 1TNF, 207113_s_at, 259_s_at, 2AZ5, 2E7A, 2TUN, 2ZJC, 2ZPX, 3ALQ, 3IT8, 3L9J, 3WD5, 4G3Y, 4TSV, 4TWT, 5TSW, 7124, A_14_P110091, A_14_P125975, A_23_P376488, A_24_P50759, AAA36758, AAA61198, AAA61200, AAC03542, AAD18091, AAF71992, AAH28148, AAL47581, AAO21132, AB088112, AB103618, AB202113, ADV31546, AF043342, AF098751, AF129756, AHJ25918, AHJ25919, AHJ25920, AHJ25921, AHJ25922, AHJ25923, AHJ25924, AHJ25925, AK314960, AY066019, AY214167, BA000025, BAB63396, BAC54944, BAE78639, BAF31279, BAG37464, BC028148, CAA25650, CAA26669, CAA75070, CAA78745, CCDS4702, CH471081, EAX03424, ENSG00000204490, ENSG00000206439, ENSG00000223952, ENSG00000228321, ENSG00000228849, ENSG00000230108, ENSG00000232810, ENSP00000365290, ENSP00000372988, ENSP00000389490, ENSP00000389492, ENSP00000392858, ENSP00000398698, ENSP00000410668, ENST00000376122, ENST00000383496, ENST00000412275, ENST00000420425, ENST00000443707, ENST00000448781, ENST00000449264, EntrezGene:7124, g10835154_3p_a_at, GE59636, HGNC:11892, HPA064998, HQ201306, Hs.241570, ILMN_1728106, IPR002959, IPR006052, IPR006053, IPR008983, IPR021184, KF887965, KF887966, KF887967, KF887968, KF887969, KF887970, KF887971, KF887972, M10988, M16441, M26331, MIM:191160, MIM:607507, MIM:610424, MIM:611162, NM_000594, NP_000585, OTTHUMP00000014621, OTTHUMP00000029281, OTTHUMP00000029720, OTTHUMP00000037669, OTTHUMP00000193290, OTTHUMP00000193749, OTTHUMP00000194120, PF00229, PH_hs_0012958, PR01234, PR01235, Q5STB3, REACT_111045, REACT_111102, REACT_1432, REACT_1619, REACT_27161, REACT_355072, SM00207, TNF, TNF-001, uc003nui.4, UPI000000D745, X01394, X02910, X02910_at, Y14768, Z15026
Secondary Identifiers TNFA_HUMAN, O43647, Q9P1Q2, Q9UIV3
Gene Names TNF, TNFA, TNFSF2
Chain chain:1-233, chain:1-39, chain:1-35, chain:50-, chain:52-, chain:77-233
This entry is a component of:
Reference Genes
Database Identifier
dbSNP Gene 7124
CTD Gene 7124
BioGPS Gene 7124
NCBI Gene 7124
ENSEMBL ENSG00000206439
KEGG Gene 7124
Orphanet 16877
Reference Transcripts
Database Identifier
RefSeq NM_000594
Cross References
Database Identifier
RefSeq NP_000585
ZINC_target P01375
DOCK Blaster 3L9J, 1A8M, 1TNF, 2AZ5, 2E7A, 2TUN, 2ZJC, 2ZPX, 3ALQ, 3IT8, 3WD5, 4G3Y, 4TSV, 4TWT, 5TSW
HMDB_protein HMDBP02070
PRO P01375
GeneCards P01375
UCSC human P01375
Protein Data Bank 3L9J, 1A8M, 1TNF, 2AZ5, 2E7A, 2TUN, 2ZJC, 2ZPX, 3ALQ, 3IT8, 3WD5, 4G3Y, 4TSV, 4TWT, 5TSW