CDT1 association with the CDC6:ORC:origin complex

Stable Identifier
Homo sapiens
Locations in the PathwayBrowser

Initiation protein Cdt1 was first identified in X. laevis, where it has been shown to be the second component of licensing factor (RLF-B) and in S. pombe. Cdt1 homologs have been identified in D. melanogaster, humans, and S. cerevisiae. Genetic studies in S. pombe have shown that binding of Cdc6 to chromatin requires the prior binding of Cdc18, the S. pombe homolog of Cdc6. In humans, the function of CDT1 is regulated during the cell cycle by its tight association with an inhibitory factor, geminin.

Literature References
PubMed ID Title Journal Year
9442876 Initiation of DNA replication in eukaryotic cells.

Dutta, A, Bell, SP

Annu Rev Cell Dev Biol 1998
10766247 XCDT1 is required for the assembly of pre-replicative complexes in Xenopus laevis.

Maiorano, D, Moreau, J, Méchali, M

Nature 2000
9635433 Geminin, an inhibitor of DNA replication, is degraded during mitosis.

McGarry, TJ, Kirschner, MW

Cell 1998
11836525 Interdependent nuclear accumulation of budding yeast Cdt1 and Mcm2-7 during G1 phase.

Tanaka, S, Diffley, JF

Nat Cell Biol 2002
10898791 Drosophila double parked: a conserved, essential replication protein that colocalizes with the origin recognition complex and links DNA replication with mitosis and the down-regulation of S phase transcripts.

Whittaker, AJ, Royzman, I, Orr-Weaver, TL

Genes Dev 2000
11125146 Inhibition of eukaryotic DNA replication by geminin binding to Cdt1.

Wohlschlegel, JA, Dwyer, BT, Dhar, SK, Cvetic, C, Walter, JC, Dutta, A

Science 2000
10766248 The Cdt1 protein is required to license DNA for replication in fission yeast.

Nishitani, H, Lygerou, Z, Nishimoto, T, Nurse, P

Nature 2000
11175741 Repression of origin assembly in metaphase depends on inhibition of RLF-B/Cdt1 by geminin.

Tada, S, Li, A, Maiorano, D, Méchali, M, Blow, JJ

Nat Cell Biol 2001
Participant Of
Orthologous Events
Cross References
BioModels Database