Reactome: A Curated Pathway Database

Leading Strand Synthesis

Stable Identifier
R-HSA-69109
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The processive complex is responsible for synthesizing at least 5-10 kb of DNA in a continuous manner during leading strand synthesis. The incorporation of nucleotides by pol delta is quite accurate. However, incorporation of an incorrect nucleotide does occur occasionally. Misincorporated nucleotides are removed by the 3' to 5' exonucleolytic proofreading capability of pol delta.

Literature References
Participants
Participant Of
Orthologous Events