Reactome: A Curated Pathway Database

Removal of the Flap Intermediate

Stable Identifier
R-HSA-69166
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Two endonucleases, Dna2 and flap endonuclease 1 (FEN-1), are responsible for resolving the nascent flap structure (Tsurimoto and Stillman 1991). The Dna2 endonuclease/helicase in yeast is a monomer of approximately 172 kDa. Human FEN-1 is a single polypeptide of approximately 42 kDa. Replication Protein A regulates the switching of endonucleases during the removal of the displaced flap.

Literature References
Participants
Participant Of
Orthologous Events