Reactome: A Curated Pathway Database

Processive synthesis on the lagging strand

Stable Identifier
R-HSA-69183
Type
Pathway
Species
Homo sapiens
Compartment
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Summation

The key event that allows the processive synthesis on the lagging strand, is polymerase switching from pol alpha to pol delta, as on the leading strand. However, the processive synthesis on the lagging strand proceeds very differently. DNA synthesis is discontinuous, and involves the formation of short fragments called the Okazaki fragments. During the synthesis of Okazaki fragments, the RNA primer is folded into a single-stranded flap, which is removed by endonucleases. This is followed by the ligation of adjacent Okazaki fragments.

Literature References
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Orthologous Events