Reactome: A Curated Pathway Database

G1/S-Specific Transcription

Stable Identifier
R-HSA-69205
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The E2F family of transcription factors regulate the transition from the G1 to the S phase in the cell cycle. E2F activity is regulated by members of the retinoblastoma protein (pRb) family, resulting in the tight control of the expression of E2F-responsive genes. Phosphorylation of pRb by cyclin D:CDK complexes releases pRb from E2F, inducing E2F-targeted genes such as cyclin E.

Participants
Participant Of
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Orthologous Events