Reactome: A Curated Pathway Database
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Ubiquitin-dependent degradation of Cyclin D1

Stable Identifier
R-HSA-69229
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

After the Cyclin D serves the role of mediating reactions by Cdk4 and Cdk6, it is shuttled to the cytoplasm and degraded in a ubiquitin-dependent manner. Whether Cdk4 and Cdk6 are truly redundant is a topic still under investigation, although both the kinases are required for normal cell cycle progression.

Destruction of the D type cyclins accompanies the end of the G1 phase, and the E type cyclins are involved in transition of the cell from G1 to S phase.

Participants
Participant Of
Orthologous Events