Reactome: A Curated Pathway Database

Cyclin A/B1/B2 associated events during G2/M transition

Stable Identifier
R-HSA-69273
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

Cell cycle progression is regulated by cyclin-dependent protein kinases at both the G1/S and the G2/M transitions. The G2/M transition is regulated through the phosphorylation of nuclear lamins and histones (reviewed in Sefton, 2001).
The two B-type cyclins localize to different regions within the cell and are thought to have specific roles as CDK1-activating subunits (see Bellanger et al., 2007). Cyclin B1 is primarily cytoplasmic during interphase and translocates into the nucleus at the onset of mitosis (Jackman et al., 1995; Hagting et al., 1999). Cyclin B2 colocalizes with the Golgi apparatus and contributes to its fragmentation during mitosis (Jackman et al., 1995; Draviam et al., 2001).

Literature References
Participants
events
Participant Of
hasEvent
Orthologous Events