Reactome: A Curated Pathway Database

G2/M Transition (R-HSA-69275)

Species Homo sapiens


Cyclin A can also form complexes with Cdc2 (Cdk1). Together with three B-type cyclins, Cdc2 (Cdk1) regulates the transition from G2 into mitosis. These complexes are activated by dephosphorylation of T14 and Y15. Cyclin A, B - Cdc2 complexes phosphorylate several proteins involved in mitotic spindle structure and function, the breakdown of the nuclear envelope, and topological changes in chromosomes allowing resolution of their entanglement and condensation that is necessary for the ~2 meters of DNA to be segregated at mitosis.

Locations in the PathwayBrowser
Additional Information
GO Biological Process G2/M transition of mitotic cell cycle (0000086)