Reactome: A Curated Pathway Database

Dimerization of procaspase-8 (R-HSA-69416) [Homo sapiens]


Procaspase-8 monomers undergo dimerization. The dimerization event occurs at death-inducing signaling complex (DISC) and results in a reposition of the procaspase-8 inter-subunit linker to become accessible for intermolecular processing by the associated procaspase-8 molecule [Keller N et al 2010; Oberst A et al 2010].

Cross References
Database Identifier
BioModels Database BIOMD0000000243, BIOMD0000000523, BIOMD0000000525, BIOMD0000000526, BIOMD0000000407, BIOMD0000000524, BIOMD0000000220