Reactome: A Curated Pathway Database

Dimerization of procaspase-8

Stable Identifier
R-HSA-69416
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

Procaspase-8 monomers undergo dimerization. The dimerization event occurs at death-inducing signaling complex (DISC) and results in a reposition of the procaspase-8 inter-subunit linker to become accessible for intermolecular processing by the associated procaspase-8 molecule [Keller N et al 2010; Oberst A et al 2010].

Literature References
Participants
Participant Of
Orthologous Events
Cross References