Reactome: A Curated Pathway Database

Phosphorylation of MDM2 at serine-395 by ATM kinase (R-HSA-69491)

Species Homo sapiens


At the beginning of this reaction, 1 molecule of 'Mdm2' is present. At the end of this reaction, 1 molecule of 'phospho-MDM2' is present.

This reaction takes place in the 'nucleoplasm' and is mediated by the 'kinase activity' of 'phospho-ATM (Ser 1981)'.

Locations in the PathwayBrowser
Additional Information
Compartment nucleoplasm
Components of this entry
Input entries
Output entries
Catalyst Activity
PhysicalEntity Activity Active Units
p-S1981,Ac-K3016-ATM protein serine/threonine kinase activity (0004674)
Literature References
pubMedId Title Journal Year
11331603 ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage. Genes Dev 2001