At the beginning of this reaction, 1 molecule of 'Mdm2' is present. At the end of this reaction, 1 molecule of 'phospho-MDM2' is present.
This reaction takes place in the 'nucleoplasm' and is mediated by the 'kinase activity' of 'phospho-ATM (Ser 1981)'.
|p-S1981,Ac-K3016-ATM||protein serine/threonine kinase activity (0004674)|
|11331603||ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage.||Genes Dev||2001|