Reactome: A Curated Pathway Database

Phosphorylation of p53 at ser-15 by ATM kinase (R-HSA-69511)

Species Homo sapiens

Summation

In response to DNA double strand breaks, serine at position 15 of the TP53 (p53) tumor suppressor protein is rapidly phosphorylated by the ATM kinase. This serves to stabilize the p53 protein. A rise in the levels of the p53 protein induces the expression of p21 cyclin-dependent kinase inhibitor. This prevents the normal progression from G1 to S phase, thus providing a check on replication of damaged DNA (Banin et al. 1998, Canman et al. 1998, Khanna et al. 1998).

Locations in the PathwayBrowser
Additional Information
Compartment nucleoplasm
Components of this entry
Input entries
Output entries
Catalyst Activity
PhysicalEntity Activity Active Units
p-S1981-ATM protein serine/threonine kinase activity (0004674)
Cross References
Database Identifier
IntAct MINT-49767