p53 causes G1 arrest by inducing the expression of a cell cycle inhibitor, p21 (El-Deiry et al, 1993; Harper et al, 1993; Xiong et al, 1993). P21 binds and inactivates Cyclin-Cdk complexes that mediate G1/S progression, resulting in lack of phosphorylation of Rb, E2F sequestration and cell cycle arrest at the G1/S transition. Mice with a homozygous deletion of p21 gene are deficient in their ability to undergo a G1/S arrest in response to DNA damage (Deng et al, 1995).
|8242752||WAF1, a potential mediator of p53 tumor suppression.||Cell||1993|
|8242751||The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.||Cell||1993|
|8259214||p21 is a universal inhibitor of cyclin kinases.||Nature||1994|
|7664346||Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control.||Cell||1995|