Reactome: A Curated Pathway Database

p53-Independent DNA Damage Response

Stable Identifier
R-HSA-69610
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

In response to DNA damage due to exposure to ultraviolet light or to ionizing radiation, Cdc25A is phosphorylated by Chk1 or Chk2. The phosphorylation of Cdc25A at ser-123, in response to DNA damage from ionizing radiation is a signal for ubiquitination and subsequent degradation of Cdc25A. The destruction of Cdc25A prevents the normal G1/S transition. Cdc25A is required for the activation of the Cyclin E:Cdk2 complexes via dephosphorylation.

Chk1 is activated in response to DNA damage due to uv light. However, the phosphorylation occurs at a different site.

Literature References
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Orthologous Events