G1/S DNA Damage Checkpoints

Stable Identifier
R-HSA-69615
DOI
10.3180/REACT_2254.1
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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G1/S DNA Damage Checkpoints
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In the G1 phase there are two types of DNA damage responses, the p53-dependent and the p53-independent pathways. The p53-dependent responses inhibit CDKs through the up-regulation of genes encoding CKIs mediated by the p53 protein, whereas the p53-independent mechanisms inhibit CDKs through the inhibitory T14Y15 phosphorylation of Cdk2. Failure of DNA damage checkpoints in G1 leads to mutagenic replication of damaged templates and other replication defects.
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Orthologous Events
G1/S DNA Damage Checkpoints (Bos taurus)
G1/S DNA Damage Checkpoints (Caenorhabditis elegans)
G1/S DNA Damage Checkpoints (Canis familiaris)
G1/S DNA Damage Checkpoints (Danio rerio)
G1/S DNA Damage Checkpoints (Dictyostelium discoideum)
G1/S DNA Damage Checkpoints (Drosophila melanogaster)
G1/S DNA Damage Checkpoints (Gallus gallus)
G1/S DNA Damage Checkpoints (Mus musculus)
G1/S DNA Damage Checkpoints (Rattus norvegicus)
G1/S DNA Damage Checkpoints (Saccharomyces cerevisiae)
G1/S DNA Damage Checkpoints (Schizosaccharomyces pombe)
G1/S DNA Damage Checkpoints (Sus scrofa)
G1/S DNA Damage Checkpoints (Xenopus tropicalis)
Authored
Hoffmann, I  (2003-06-05)
Khanna, KK  (2003-06-05)
Created
Walworth, N  (2003-06-05)
O'Donnell, M  (2003-06-05)
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