Reactome: A Curated Pathway Database

Phosphorylation and activation of CHEK2 by ATM (R-HSA-69891)

Species Homo sapiens

Summation

Activated ATM phosphorylates CHEK2 (CHK2, Cds1) on threonine residue T68 (Matsuoka et al. 2000, Melchionna et al. 2000). The presence of BRCA1 and TP53BP1 positively regulates ATM-mediated phosphorylation of CHEK2 (Wang et al. 2002, Foray et al. 2003). ATM-mediated phosphorylation causes formation of CHEK2 dimers and dissociation of CHEK2 from chromatin (Li and Stern 2005).

Locations in the PathwayBrowser
Additional Information
Compartment nucleoplasm