Transcriptional activation of cell cycle inhibitor p21

Stable Identifier
R-HSA-69895
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

Both p53-independent and p53-dependent mechanisms of induction of p21 mRNA have been demonstrated. p21 is transcriptionally activated by p53 after DNA damage (el-Deiry et al., 1993).

Literature References
PubMed ID Title Journal Year
8242752 WAF1, a potential mediator of p53 tumor suppression. Cell 1993
Participants
Participant Of
Orthologous Events