Reactome: A Curated Pathway Database

Transcriptional activation of cell cycle inhibitor p21 (R-HSA-69895)

Species Homo sapiens


Both p53-independent and p53-dependent mechanisms of induction of p21 mRNA have been demonstrated. p21 is transcriptionally activated by p53 after DNA damage (el-Deiry et al., 1993).

Locations in the PathwayBrowser
Cross References
Database Identifier
BioModels Database BIOMD0000000154, BIOMD0000000155, BIOMD0000000287, BIOMD0000000157, BIOMD0000000158, BIOMD0000000156
Literature References
pubMedId Title Journal Year
8242752 WAF1, a potential mediator of p53 tumor suppression. Cell 1993