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Fructose catabolism

Stable Identifier
R-HSA-70350
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

Fructose occurs naturally in foods as a free monosaccharide and as a component of the disaccharide sucrose. It is also widely used as a sweetener. In the body, fructose catabolism occurs in the liver and to a lesser extent in the kidney and small intestine. In these tissues, it is converted to dihydroxyacetone phosphate and D-glyceraldehyde 3-phosphate, two intermediates in the glycolytic pathway, in a sequence of three reactions. It is phosphorylated to form fructose 1-phosphate, which is cleaved by aldolase to yield dihydroxyacetone phosphate and D-glyceraldehyde, and the latter compound is phosphorylated to yield D-glyceraldehyde 3-phosphate. Other pathways exist for the conversion of D-glyceraldehyde to intermediates of glycolysis, but these appear to play only a minor role in normal fructose metabolism (Sillero et al. 1969).

Literature References
PubMed ID Title Journal Year
5823111 Enzymes involved in fructose metabolism in liver and the glyceraldehyde metabolic crossroads Eur. J. Biochem. 1969
8213607 Intermediary metabolism of fructose Am. J. Clin. Nutr. 1993
Participants
Participant Of
Event Information
Orthologous Events
Cross References