Reactome: A Curated Pathway Database

Fructose catabolism (R-HSA-70350)

Species Homo sapiens


Fructose occurs naturally in foods as a free monosaccharide and as a component of the disaccharide sucrose. It is also widely used as a sweetener. In the body, fructose catabolism occurs in the liver and to a lesser extent in the kidney and small intestine. In these tissues, it is converted to dihydroxyacetone phosphate and D-glyceraldehyde 3-phosphate, two intermediates in the glycolytic pathway, in a sequence of three reactions. It is phosphorylated to form fructose 1-phosphate, which is cleaved by aldolase to yield dihydroxyacetone phosphate and D-glyceraldehyde, and the latter compound is phosphorylated to yield D-glyceraldehyde 3-phosphate. Other pathways exist for the conversion of D-glyceraldehyde to intermediates of glycolysis, but these appear to play only a minor role in normal fructose metabolism (Sillero et al. 1969).

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Literature References
pubMedId Title Journal Year
8213607 Intermediary metabolism of fructose Am. J. Clin. Nutr. 1993
5823111 Enzymes involved in fructose metabolism in liver and the glyceraldehyde metabolic crossroads Eur. J. Biochem. 1969