Reactome: A Curated Pathway Database

D-Glucose 1-phosphate <=> alpha-D-Glucose 6-phosphate (R-HSA-70427)

Species Homo sapiens


Cytosolic phosphoglucomutase (PGM) catalyzes the reversible conversion of glucose 1-phosphate to glucose 6-phosphate. Two PGM isoenzymes, both monomers, have been identified. PGM1 is the major form found in most tissues except erythrocytes, where PGM2 is abundant (March et al. 1993; Parrington et al. 1968; Putt et al. 1993). PGM2 also has substantial phosphopentomutase activity and its primary physiological in normal tissues in vivo is not clear.

Locations in the PathwayBrowser
Additional Information
Compartment cytosol
Reverse Reaction PGM1:Mg2+,PGM2:Mg2+ isomerise G6P to G1P
Components of this entry
Input entries
Output entries
Catalyst Activity
PhysicalEntity Activity Active Units
PGM1:Mg2+, PGM2:Mg2+ phosphoglucomutase activity (0004614)
Literature References
pubMedId Title Journal Year
7902568 The classical human phosphoglucomutase (PGM1) isozyme polymorphism is generated by intragenic recombination Proc Natl Acad Sci U S A 1993