Reactome: A Curated Pathway Database

D-Glucose 1-phosphate <=> alpha-D-Glucose 6-phosphate

Stable Identifier
R-HSA-70427
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Cytosolic phosphoglucomutase (PGM) catalyzes the reversible conversion of glucose 1-phosphate to glucose 6-phosphate. Two PGM isoenzymes, both monomers, have been identified. PGM1 is the major form found in most tissues except erythrocytes, where PGM2 is abundant (March et al. 1993; Parrington et al. 1968; Putt et al. 1993). PGM2 also has substantial phosphopentomutase activity and its primary physiological in normal tissues in vivo is not clear.

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
phosphoglucomutase activity of PGM1:Mg2+, PGM2:Mg2+ [cytosol] PGM1:Mg2+, PGM2:Mg2+ [cytosol] phosphoglucomutase activity (0004614)
Orthologous Events