Reactome: A Curated Pathway Database

D-Glucose 1-phosphate <=> alpha-D-Glucose 6-phosphate (R-HSA-70427) [Homo sapiens]


Cytosolic phosphoglucomutase (PGM) catalyzes the reversible conversion of glucose 1-phosphate to glucose 6-phosphate. Two PGM isoenzymes, both monomers, have been identified. PGM1 is the major form found in most tissues except erythrocytes, where PGM2 is abundant (March et al. 1993; Parrington et al. 1968; Putt et al. 1993). PGM2 also has substantial phosphopentomutase activity and its primary physiological in normal tissues in vivo is not clear.

Additional Information
Compartment cytosol
Reverse Reaction PGM1:Mg2+,PGM2:Mg2+ isomerise G6P to G1P
Components of this entry
Input entries
Output entries
Catalyst Activity
PhysicalEntity Activity Active Units
PGM1:Mg2+, PGM2:Mg2+ phosphoglucomutase activity (0004614)  
Literature References
pubMedId Title Journal Year
7902568 The classical human phosphoglucomutase (PGM1) isozyme polymorphism is generated by intragenic recombination Proc Natl Acad Sci U S A 1993