Cytosolic phosphoglucomutase (PGM) catalyzes the reversible conversion of glucose 1-phosphate to glucose 6-phosphate. Two PGM isoenzymes, both monomers, have been identified. PGM1 is the major form found in most tissues except erythrocytes, where PGM2 is abundant (March et al. 1993; Parrington et al. 1968; Putt et al. 1993). PGM2 also has substantial phosphopentomutase activity and its primary physiological in normal tissues in vivo is not clear.
|Reverse Reaction||PGM1:Mg2+,PGM2:Mg2+ isomerise G6P to G1P|
|PGM1:Mg2+, PGM2:Mg2+||phosphoglucomutase activity (0004614)|
|7902568||The classical human phosphoglucomutase (PGM1) isozyme polymorphism is generated by intragenic recombination||Proc Natl Acad Sci U S A||1993|