Reactome: A Curated Pathway Database

D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+

Stable Identifier
R-HSA-70449
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
Glyceraldehyde 3 phosphate, NAD+, and orthophosphate react to form 1,3 bisphosphoglycerate and NADH + H+
Locations in the PathwayBrowser
Summation

Cytosolic glyceraldehyde 3-phosphate dehydrogenase catalyzes the reversible reaction of glyceraldehyde 3-phosphate, orthophosphate, and NAD+ to form NADH + H+ and 1,3-bisphosphoglycerate, the first energy rich intermediate of glycolysis. The biochemical details of this reaction were worked out by C and G Cori and their colleagues (Taylor et al. 1948; Cori et al. 1948).

While there are multiple human glyceraldehyde 3-phosphate dehydrogenase-like pseudogenes, there is only one glyceraldehyde 3-phosphate dehydrogenase gene expressed in somatic tissue (Benham and Povey 1989; Heinz and Freimuller 1982; Ercolani et al. 1988), and studies of aged human erythrocytes suggest that variant forms of the enzyme arise as a result of post-translational modifications (Edwards et al. 1976). There is, however, an authentic second isoform of glyceraldehyde 3-phosphate dehydrogenase whose expression is confined to spermatogenic cells of the testis (Welch et al. 2000).

Literature References
Participants
Participant Of
hasEvent
This entity is regulated by:
Title Physical Entity Activity
glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity of glyceraldehyde-3-phosphate dehydrogenase tetramer [cytosol] glyceraldehyde-3-phosphate dehydrogenase tetramer [cytosol] glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity (0004365)
Orthologous Events
Cross References
Rhea