Reactome: A Curated Pathway Database

alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate (R-HSA-70471) [Homo sapiens]


Cytosolic phosphoglucose isomerase catalyzes the reversible interconversion of glucose 6-phosphate and fructose 6-phosphate (Tsuboi et al. 1958; Noltmann 1972; Bloxham and Lardy 1973). The active form of the enzyme is a homodimer (Read et al. 2001). Mutations in the enzyme are associated with hemolytic anemia (Xu and Beutler 1994).

Additional Information
Compartment cytosol
Reverse Reaction D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate
Components of this entry
Input entries
Output entries
Catalyst Activity
PhysicalEntity Activity Active Units
glucose 6-phosphate isomerase dimer glucose-6-phosphate isomerase activity (0004347)