Reactome: A Curated Pathway Database

alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate

Stable Identifier
R-HSA-70471
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
Glucose 6-phosphate is isomerized to form fructose-6-phosphate
Locations in the PathwayBrowser
Summation

Cytosolic phosphoglucose isomerase catalyzes the reversible interconversion of glucose 6-phosphate and fructose 6-phosphate (Tsuboi et al. 1958; Noltmann 1972; Bloxham and Lardy 1973). The active form of the enzyme is a homodimer (Read et al. 2001). Mutations in the enzyme are associated with hemolytic anemia (Xu and Beutler 1994).

Literature References
Participants
Participant Of
hasEvent
This entity is regulated by:
Title Physical Entity Activity
glucose-6-phosphate isomerase activity of glucose 6-phosphate isomerase dimer [cytosol] glucose 6-phosphate isomerase dimer [cytosol] glucose-6-phosphate isomerase activity (0004347)
Orthologous Events