Cytosolic phosphoglucose isomerase catalyzes the reversible interconversion of glucose 6-phosphate and fructose 6-phosphate (Tsuboi et al. 1958; Noltmann 1972; Bloxham and Lardy 1973). The active form of the enzyme is a homodimer (Read et al. 2001). Mutations in the enzyme are associated with hemolytic anemia (Xu and Beutler 1994).
|Reverse Reaction||D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate|
|glucose 6-phosphate isomerase dimer||glucose-6-phosphate isomerase activity (0004347)|
|The Enzymes, 3rd ed||1973|
|The Enzymes, 3rd ed||1972|
|11371164||The crystal structure of human phosphoglucose isomerase at 1.6 A resolution: implications for catalytic mechanism, cytokine activity and haemolytic anaemia||J Mol Biol||2001|
|13538944||Enzymes of the human erythrocyte. IV. Phosphoglucose isomerase, purification and properties.||J Biol Chem||1958|
|7989588||The characterization of gene mutations for human glucose phosphate isomerase deficiency associated with chronic hemolytic anemia||J Clin Invest||1994|