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LDH tetramer oxidises LACT to PYR

Stable Identifier
R-HSA-70510
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
(S)-Lactate + NAD+ <=> Pyruvate + NADH + H+
Locations in the PathwayBrowser
Summation

Cytosolic lactate dehydrogenase catalyzes the freely reversible reaction of lactate and NAD+ to form pyruvate and NADH + H+. In liver parenchymal cells, this reaction allows lactate from red blood cells and exercising muscle to be converted to pyruvate which in turn is typically used for gluconeogenesis which also consumes the NADH from the reaction.

Lactate dehydrogenase is active as a tetramer. Two isoforms of lactate dehydrogenase, A and B, are widely expressed in human tissues, and all five tetramers - A4, A3B, A2B2, AB3, and B4 - are found (Read et al. 2001; Sakai et al. 1987; Yu et al. 2001). A third isoform, C, and its tetramer, C4, are found in testis (Millan et al. 1987; LeVan & Goldberg 1991). A fourth isoform, LDHAL6A, is less fully characterized than these others but limited data suggest that it may be testis-specific (Chen et al. 2009).

Participants
Participant Of
Event Information
Catalyst Activity
Catalyst Activity
Title
L-lactate dehydrogenase activity of LDH tetramer [cytosol]
Physical Entity
Activity
Orthologous Events