Reactome: A Curated Pathway Database

alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+

Stable Identifier
R-HSA-70941
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Alpha-aminoadipic semialdehyde dehydrogenase (ALDH7A1) catalyzes the reaction of alpha-aminoadipic semialdehyde and NAD+ to form alpha-aminoadipate and NADH + H+ (Mills et al. 2006). Unpublished crystallographic data (PDB 2J6L) indicate that the enzyme is a homodimer. Recent immunofluorescence studies of both endogenous and GFP-tagged ALDH7A1 proteins in cultured human embryonic kidney cells indicate that the protein is present in both mitochondria and the cytosol (Wong et al. 2010).

Literature References
PubMed ID Title Journal Year
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
L-aminoadipate-semialdehyde dehydrogenase activity of ALDH7A1 tetramer [mitochondrial matrix] ALDH7A1 tetramer [mitochondrial matrix] L-aminoadipate-semialdehyde dehydrogenase activity (0004043)
Orthologous Events
Cross References
Rhea