Reactome: A Curated Pathway Database

Propionyl-CoA catabolism (R-HSA-71032)

Species Homo sapiens


Propionyl-CoA is a product of the catabolism of the amino acids, leucine, methionine, and threonine, and of the beta-oxidation of fatty acids with odd numbers of carbon atoms. The three reactions of this pathway convert propionyl-CoA to succinyl-CoA, an intermediate of the citric acid cycle. Through these reactions, carbon atoms from these sources can be fully oxidized to produce energy, or can be directed to gluconeogenesis. The three reactions of propionyl-CoA catabolism take place in the mitochondrial matrix.

Locations in the PathwayBrowser
Additional Information
Compartment mitochondrial matrix
GO Biological Process short-chain fatty acid catabolic process (0019626)
Literature References
pubMedId Title Journal Year
The Metabolic and Molecular Bases of Inherited Disease, 8th ed 2001