Reactome: A Curated Pathway Database

Creatine metabolism (R-HSA-71288) [Homo sapiens]


In humans, creatine is synthesized primarily in the liver and kidney, from glycine, arginine, and S-adenosylmethionine, in a sequence of two reactions. From the liver, creatine is exported to tissues such as skeletal muscle and brain, where it undergoes phosphorylation and serves as a short-term energy store. The mechanism by which creatine leaves producer tissues is unclear, but its uptake by consumer tissues is mediated by the SLC6A8 transporter.

Once formed, phosphocreatine undergoes a slow spontaneous reaction to form creatinine, which is excreted from the body.

Cross References
Database Identifier
BioModels Database BIOMD0000000570, BIOMD0000000554, BIOMD0000000248
Literature References
pubMedId Title Journal Year
10893433 Creatine and creatinine metabolism Physiol Rev 2000