Reactome: A Curated Pathway Database

6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+

Stable Identifier
R-HSA-71299
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Cytosolic phosphogluconate dehydrogenase (PGD) catalyzes the reaction of 6-phospho-D-gluconate and NADP+ to form D-ribulose 5-phosphate, CO2, and NADPH + H+ (Beutler and Kuhl 1985; Rippa et al. 1998). The PGD enzyme is dimeric (Dallocchio et al. 1985).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
phosphogluconate dehydrogenase (decarboxylating) activity of PGD dimer [cytosol] PGD dimer [cytosol] phosphogluconate dehydrogenase (decarboxylating) activity (0004616)
Orthologous Events
Cross References
Rhea