Reactome: A Curated Pathway Database

6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (R-HSA-71299) [Homo sapiens]


Cytosolic phosphogluconate dehydrogenase (PGD) catalyzes the reaction of 6-phospho-D-gluconate and NADP+ to form D-ribulose 5-phosphate, CO2, and NADPH + H+ (Beutler and Kuhl 1985; Rippa et al. 1998). The PGD enzyme is dimeric (Dallocchio et al. 1985).

Additional Information
Compartment cytosol
Components of this entry
Input entries
Output entries
Catalyst Activity
PhysicalEntity Activity Active Units
PGD dimer phosphogluconate dehydrogenase (decarboxylating) activity (0004616)  
Cross References
Database Identifier
Rhea 10117, 10119
Inferred Entries
Orthologous events