Cytosolic aldolase catalyzes the cleavage of D-fructose 1,6-bisphosphate to yield dihydroxyacetone phosphate and D-glyceraldehyde 3-phosphate. The active form of aldolase is a homotetramer. Three aldolase isozymes have been identified which differ in their patterns of expression in various adult tissues and during development but are otherwise functionally indistinguishable (Ali and Cox 1995; Freemont et al. 1984, 1988).
|Reverse Reaction||dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate <=> D-fructose 1,6-bisphosphate|
|aldolase tetramer||fructose-bisphosphate aldolase activity (0004332)|
|7717389||Diverse mutations in the aldolase B gene that underlie the prevalence of hereditary fructose intolerance||Am J Hum Genet||1995|
|6696436||Human skeletal-muscle aldolase: N-terminal sequence analysis of CNBr- and o-iodosobenzoic acid-cleavage fragments||Arch Biochem Biophys||1984|
|3355497||The complete amino acid sequence of human skeletal-muscle fructose-bisphosphate aldolase||Biochem J||1988|