Reactome: A Curated Pathway Database

G6PC hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (liver) (R-HSA-71825)

Species Homo sapiens


Glucose-6-phosphatase (G6PC) associated with the inner face of the endoplasmic reticulum membrane catalyzes the hydrolysis of glucose-6-phosphate to glucose and orthophosphate. This reaction is essentially irreversible (Lei et al. 1993, Ghosh et al. 2002). Defects in glucose-6-phosphatase are the cause of glycogen storage disease type 1a (Lei et al. 1993, 1995, Chou and Mansfield 2008).

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Additional Information
Compartment endoplasmic reticulum lumen , endoplasmic reticulum membrane
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Catalyst Activity
PhysicalEntity Activity Active Units
G6PC glucose-6-phosphatase activity (0004346)