Reactome: A Curated Pathway Database

G6PC hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (liver)

Stable Identifier
R-HSA-71825
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
alpha-D-Glucose 6-phosphate + H2O => alpha-D-Glucose + Orthophosphate (G6PC - liver)
Locations in the PathwayBrowser
Summation

Glucose-6-phosphatase (G6PC) associated with the inner face of the endoplasmic reticulum membrane catalyzes the hydrolysis of glucose-6-phosphate to glucose and orthophosphate. This reaction is essentially irreversible (Lei et al. 1993, Ghosh et al. 2002). Defects in glucose-6-phosphatase are the cause of glycogen storage disease type 1a (Lei et al. 1993, 1995, Chou and Mansfield 2008).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
glucose-6-phosphatase activity of G6PC [endoplasmic reticulum membrane] G6PC [endoplasmic reticulum membrane] glucose-6-phosphatase activity (0004346)
Orthologous Events