Reactome: A Curated Pathway Database

1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ADP (R-HSA-71850)

Species Homo sapiens


Cytosolic phosphoglycerate kinase catalyzes the reaction of ADP and 1,3-bisphosphoglycerate to form D glyceraldehyde 3-phosphate and ATP. The active form of the enzyme is a monomer and requires Mg++ (Yoshida and Watanabe 1972; Huang et al. 1980a,b). This is the first substrate level phosphorylation reaction in glycolysis.

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Additional Information
Compartment cytosol
Reverse Reaction ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate
Components of this entry
Input entries
Output entries
Catalyst Activity
PhysicalEntity Activity Active Units
phosphoglycerate kinase 1 complex phosphoglycerate kinase activity (0004618)