The splicing of a subset of pre-mRNA introns occurs by a second pathway, designated the AT-AC or U12-dependent splicing pathway. AT-AC introns have highly conserved, non-canonical splice sites that are removed by the AT-AC spliceosome, which contains distinct snRNAs (U11, U12, U4atac, U6atac) that are structurally and functionally analogous to the major spliceosome. U5 snRNA as well as many of the protein factors appear to be conserved between the two spliceosomes.
|GO Biological Process||mRNA splicing, via spliceosome (0000398)|
|9149533||Pre-mRNA splicing: the discovery of a new spliceosome doubles the challenge.||Trends Biochem Sci||1997|
|10207048||AT-AC pre-mRNA splicing mechanisms and conservation of minor introns in voltage-gated ion channel genes.||Mol Cell Biol||1999|