Reactome: A Curated Pathway Database

mRNA Splicing - Minor Pathway (R-HSA-72165)

Species Homo sapiens


The splicing of a subset of pre-mRNA introns occurs by a second pathway, designated the AT-AC or U12-dependent splicing pathway. AT-AC introns have highly conserved, non-canonical splice sites that are removed by the AT-AC spliceosome, which contains distinct snRNAs (U11, U12, U4atac, U6atac) that are structurally and functionally analogous to the major spliceosome. U5 snRNA as well as many of the protein factors appear to be conserved between the two spliceosomes.

Locations in the PathwayBrowser
Additional Information
Compartment nucleoplasm
GO Biological Process mRNA splicing, via spliceosome (0000398)