Reactome: A Curated Pathway Database

mRNA Splicing (R-HSA-72172) [Homo sapiens]


The process in which excision of introns from the primary transcript of messenger RNA (mRNA) is followed by ligation of the two exon termini exposed by removal of each intron, is called mRNA splicing. Most of the mRNA is spliced by the major pathway, involving the U1, U2, U4, U5 and U6 snRNPs. A minor fraction, about 1 %, of the mRNAs are spliced via the U12 dependent pathway.

Additional Information
Compartment nucleoplasm
GO Biological Process RNA splicing (0008380)
Literature References
pubMedId Title Journal Year
12226669 Comprehensive proteomic analysis of the human spliceosome. Nature 2002