Translation initiation complex formation (R-HSA-72649) [Homo sapiens]


The translation initiation complex forms when the 43S complex binds the mRNA that is associated with eIF4F, eIF4B and eIF4H. eIF4G in the eIF4F complex can directly contact eIF3 in the 43S complex. eIF1A is necessary for the formation of this complex.

Locations in the PathwayBrowser
Additional Information
Compartment cytosol
Literature References
pubMedId Title Journal Year
641056 The mechanism of action of protein synthesis initiation factors from rabbit reticulocytes. J Biol Chem 1978
592399 Initiation of mammalian protein synthesis. II. The assembly of the initiation complex with purified initiation factors. J Mol Biol 1978
6853548 New initiation factor activity required for globin mRNA translation. J Biol Chem 1983
9732867 Eukaryotic ribosomes require initiation factors 1 and 1A to locate initiation codons. Nature 1999
Inferred Entries
Orthologous events