Reactome: A Curated Pathway Database

Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S

Stable Identifier
R-HSA-72662
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The cap-binding complex is constituted by the initiation factors eIF4A, eIF4G and eIF4E. First, eIF4E must be released from the inactive eIF4E:4E-BP complex. Then eIF4A interacts with eIF4G, and eIF4E binds to the amino-terminal domain of eIF4G, resulting in the formation of the cap-binding complex eIF4F. eIF4A together with eIF4B or eIF4H is thought to unwind RNA secondary structures near the 5'-end of the mRNA. The translation initiation complex is formed when the 43S complex binds the cap-bound mRNA.

Literature References
Participants
Participant Of
Orthologous Events