Reactome: A Curated Pathway Database

Ribosomal scanning and start codon recognition

Stable Identifier
R-HSA-72702
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

The 80S ribosome bound to the mRNA moves along the mRNA molecule from its initial site to the initiation codon and forms a 48S complex, in which the initiation codon is base paired to the anticodon of the Met-tRNAi. Proper recognition of the AUG initiation codon depends on base pairing with the anticodon of the Met-tRNAi and requires eIF1, eIF1A, eIF2 and eIF5.

Literature References
Participants
Participant Of
Orthologous Events