GTP hydrolysis and joining of the 60S ribosomal subunit

Stable Identifier
R-HSA-72706
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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GTP hydrolysis and joining of the 60S ribosomal subunit
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Hydrolysis of eIF2-GTP occurs after the Met-tRNAi has recognized the AUG. This reaction is catalyzed by eIF5 (or eIF5B) and is thought to cause dissociation of all other initiation factors and allow joining of the large 60S ribosomal subunit. The 60S subunit joins - a reaction catalyzed by eIF5 or eIF5B - resulting in a translation-competent 80S ribosome. Following 60S subunit joining, eIF5B hydrolyzes its GTP and is released from the 80S ribosome, which is now ready to start elongating the polypeptide chain.
Literature References
Participants
Events
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Orthologous Events
GTP hydrolysis and joining of the 60S ribosomal subunit (Bos taurus)
GTP hydrolysis and joining of the 60S ribosomal subunit (Caenorhabditis elegans)
GTP hydrolysis and joining of the 60S ribosomal subunit (Canis familiaris)
GTP hydrolysis and joining of the 60S ribosomal subunit (Dictyostelium discoideum)
GTP hydrolysis and joining of the 60S ribosomal subunit (Drosophila melanogaster)
GTP hydrolysis and joining of the 60S ribosomal subunit (Gallus gallus)
GTP hydrolysis and joining of the 60S ribosomal subunit (Mus musculus)
GTP hydrolysis and joining of the 60S ribosomal subunit (Plasmodium falciparum)
GTP hydrolysis and joining of the 60S ribosomal subunit (Rattus norvegicus)
GTP hydrolysis and joining of the 60S ribosomal subunit (Saccharomyces cerevisiae)
GTP hydrolysis and joining of the 60S ribosomal subunit (Schizosaccharomyces pombe)
GTP hydrolysis and joining of the 60S ribosomal subunit (Sus scrofa)
GTP hydrolysis and joining of the 60S ribosomal subunit (Xenopus tropicalis)
Cross References
BioModels Database
Created
Merrick, WC  (2002-12-16)
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