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Cap-dependent Translation Initiation
Stable Identifier
R-HSA-72737
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Metabolism of proteins (Homo sapiens)
Translation (Homo sapiens)
Eukaryotic Translation Initiation (Homo sapiens)
Cap-dependent Translation Initiation (Homo sapiens)
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Translation initiation is a complex process in which the Met-tRNAi initiator, 40S, and 60S ribosomal subunits are assembled by eukaryotic initiation factors (eIFs) into an 80S ribosome at the start codon of an mRNA. The basic mechanism for this process can be described as a series of five steps: 1) formation of a pool of free 40S subunits, 2) formation of the ternary complex (Met-tRNAi/eIF2/GTP), and subsequently, the 43S complex (comprising the 40S subunit, Met-tRNAi/eIF2/GTP, eIF3 and eIF1A), 3) activation of the mRNA upon binding of the cap-binding complex eIF4F, and factors eIF4A, eIF4B and eIF4H, with subsequent binding to the 43S complex, 4) ribosomal scanning and start codon recognition, and 5) GTP hydrolysis and joining of the 60S ribosomal subunit.
Participants
Events
Formation of a pool of free 40S subunits
(Homo sapiens)
Formation of the ternary complex, and subsequently, the 43S complex
(Homo sapiens)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
(Homo sapiens)
Ribosomal scanning and start codon recognition
(Homo sapiens)
GTP hydrolysis and joining of the 60S ribosomal subunit
(Homo sapiens)
Recycling of eIF2:GDP
(Homo sapiens)
Participates
as an event of
Eukaryotic Translation Initiation (Homo sapiens)
Orthologous Events
Cap-dependent Translation Initiation (Bos taurus)
Cap-dependent Translation Initiation (Caenorhabditis elegans)
Cap-dependent Translation Initiation (Canis familiaris)
Cap-dependent Translation Initiation (Danio rerio)
Cap-dependent Translation Initiation (Dictyostelium discoideum)
Cap-dependent Translation Initiation (Drosophila melanogaster)
Cap-dependent Translation Initiation (Gallus gallus)
Cap-dependent Translation Initiation (Mus musculus)
Cap-dependent Translation Initiation (Plasmodium falciparum)
Cap-dependent Translation Initiation (Rattus norvegicus)
Cap-dependent Translation Initiation (Saccharomyces cerevisiae)
Cap-dependent Translation Initiation (Schizosaccharomyces pombe)
Cap-dependent Translation Initiation (Sus scrofa)
Cap-dependent Translation Initiation (Xenopus tropicalis)
Created
Merrick, WC (2002-12-16)
© 2024
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