D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate

Stable Identifier
R-HSA-73580
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
addition of diphosphate (PP) to ribose 5-phosphate to form 5'-Phospho-alpha-D-ribose 1-diphosphate (PRPP)
Locations in the PathwayBrowser
Summation

Cytosolic phophoribosyl pyrophosphate synthetase catalyzes the reaction of D-ribose 5-phosphate and ATP to form 5-phospho-alpha-D-ribose and AMP. Three isoforms of the enzyme have been described. The first has been purified and characterized biochemically (Fox and Kelley 1971). The others are known only as inferred protein products of cloned genes; their catalytic properties have not been determined.

Literature References
PubMed ID Title Journal Year
4328836 Human phosphoribosylpyrophosphate synthetase J Biol Chem 1971
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ribose phosphate diphosphokinase activity of PRPS2 dimer, PRPS1L dimer [cytosol]
Physical Entity
Activity
Orthologous Events