Reactome: A Curated Pathway Database

D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (R-HSA-73580)

Species Homo sapiens


Cytosolic phophoribosyl pyrophosphate synthetase catalyzes the reaction of D-ribose 5-phosphate and ATP to form 5-phospho-alpha-D-ribose and AMP. Three isoforms of the enzyme have been described. The first has been purified and characterized biochemically (Fox and Kelley 1971). The others are known only as inferred protein products of cloned genes; their catalytic properties have not been determined.

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Additional Information
Compartment cytosol
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Input entries
Output entries
Literature References
pubMedId Title Journal Year
4328836 Human phosphoribosylpyrophosphate synthetase J Biol Chem 1971
Inferred Entries
Orthologous events