Reactome: A Curated Pathway Database
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D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate

Stable Identifier
R-HSA-73580
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
addition of diphosphate (PP) to ribose 5-phosphate to form 5'-Phospho-alpha-D-ribose 1-diphosphate (PRPP)
Locations in the PathwayBrowser
Summation

Cytosolic phophoribosyl pyrophosphate synthetase catalyzes the reaction of D-ribose 5-phosphate and ATP to form 5-phospho-alpha-D-ribose and AMP. Three isoforms of the enzyme have been described. The first has been purified and characterized biochemically (Fox and Kelley 1971). The others are known only as inferred protein products of cloned genes; their catalytic properties have not been determined.

Literature References
PubMed ID Title Journal Year
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
ribose phosphate diphosphokinase activity of phosphoribosyl pyrophosphate synthetase holoenzyme [cytosol] phosphoribosyl pyrophosphate synthetase holoenzyme [cytosol] ribose phosphate diphosphokinase activity (0004749)
Orthologous Events