Reactome: A Curated Pathway Database

RNA Polymerase I Promoter Opening

Stable Identifier
R-HSA-73728
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The activity of the upstream binding factor (UBF-1) plays an important role in the regulation of rRNA synthesis. Studies reveal that phosphorylation of UBF-1 is required for its interaction with the RNA polymerase I complex, suggesting that phosphorylation of UBF-1 bound to the rDNA promoter during promoter opening modulates the assembly of the transcription initiation complex.

Participants
Participant Of
Orthologous Events