Reactome: A Curated Pathway Database

RNA Polymerase I Transcription Initiation (R-HSA-73762) [Homo sapiens]


During initiation the double-stranded DNA must be melted and transcription begins. SL1 forms and interacts with UBF-1 and the rDNA promoter. It is this platform that will recruit active RNA polymerase I to the SL1:phosphorlated UBF-1:rDNA promoter complex.

Mammalian rRNA genes are preceded by a terminator element that is recognized by the SL1 complex. This SL1 modulated acetylation of the basal Pol I transcription machinery has functional consequences suggesting that the reversible acetylation may be one way to regulate rDNA transcription.

Additional Information
Compartment nucleolus
GO Biological Process transcription initiation from RNA polymerase I promoter (0006361)