Reactome: A Curated Pathway Database

AICAR + 10-Formyl-THF => FAICAR + THF

Stable Identifier
R-HSA-73798
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
5'-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR) + 10-formyltetrahydrofolate => 5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR) + tetrahydrofolate
Locations in the PathwayBrowser
Summation

The irreversible transfer of a formyl group to 5'-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR), to yield 5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR), is catalyzed by the phosphoribosylaminoimidazolecarboxamide formyltransferase activity of the bifunctional 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase enzyme. This cytosolic protein occurs primarily as a dimer (Rayl et al. 1996; Vergis et al. 2001) and may further associate with other enzymes of de novo IMP biosynthesis under some metabolic conditions (An et al. 2008).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
phosphoribosylaminoimidazolecarboxamide formyltransferase activity of ATIC dimer [cytosol] ATIC dimer [cytosol] phosphoribosylaminoimidazolecarboxamide formyltransferase activity (0004643)
Orthologous Events
Cross References
Rhea