Reactome: A Curated Pathway Database

GAR + 10-Formyl-THF => FGAR + THF

Stable Identifier
R-HSA-73813
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
5-phosphoribosylglycinamide (GAR) + 10-formyl-tetrahydrofolate => 5'-phosphoribosylformylglycinamide (FGAR) + tetrahydrofolate
Locations in the PathwayBrowser
Summation

The irreversible transfer of a formyl group to cytosolic 5-phosphoribosylglycinamide (GAR) to form 5'-phosphoribosylformylglycinamide (FGAR) is catalyzed by the phosphoribosylglycinamide formyltransferase domain of the trifunctional protein, "phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase" (GART) (Aimi et al. 1990; Zhang et al. 2002). Fluoresence microscopy studies of cultured human cells have shown that GART is cytosolic and suggest that it may co-localize with other enzymes of de novo IMP biosynthesis under some metabolic conditions (Gooljarsingh et al. 2001; An et al. 2008).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
phosphoribosylglycinamide formyltransferase activity of GART [cytosol] GART [cytosol] phosphoribosylglycinamide formyltransferase activity (0004644)
Orthologous Events
Cross References
Rhea