Reactome: A Curated Pathway Database

Purine ribonucleoside monophosphate biosynthesis

Stable Identifier
R-HSA-73817
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The purine ribonucleotide inosine 5'-monophosphate (IMP) is assembled on 5-phospho-alpha-D-ribose 1-diphosphate (PRPP), with atoms derived from aspartate, glutamine, glycine, N10-formyl-tetrahydrofolate, and carbon dioxide. Although several of the individual reactions in this sequence are reversible, as indicated by the double-headed arrows in the diagram, other irreversible steps drive the pathway in the direction of IMP synthesis in the normal cell. All of these reactions are thus annotated here only in the direction of IMP synthesis. Guanosine 5'-monophosphate (GMP) and adenosine 5'-monophosphate (AMP) are synthesized from IMP.

Literature References
PubMed ID Title Journal Year
1574589 De novo purine nucleotide biosynthesis Prog Nucleic Acid Res Mol Biol 1992
Participants
Participant Of
Orthologous Events