Reactome: A Curated Pathway Database

Death Receptor Signalling (R-HSA-73887)

Species Homo sapiens

Summation

The death receptors, all cell-surface receptors, begin the process of caspase activation. The common feature of these type 1 transmembrane proteins is the "death-domain" a conserved cytoplasmic motif found on all of the three receptors (FAS/CD95, TNF-receptor, and TRAIL-receptor) that binds the Fas-associated protein with death domain (FADD). Ligand binding to death receptors (DR) results in receptor oligomerization and recruitment of adaptor proteins via homophilic interaction of death domains. This project describes an assembly of the death-inducing signaling complex (DISC) and shows protein composition and stoichiometry within the DISC. It also provides the appropriate literature references if available. However, the DISC signaling complex may vary in its components stoichiometry. DR signaling may trigger formation of higher order receptor structures or signaling through rearrangement of receptor chains, which is not reflected here.

Locations in the PathwayBrowser
Additional Information
GO Biological Process cell surface receptor signaling pathway (0007166)