Reactome: A Curated Pathway Database

Homologous Recombination Repair (R-HSA-73888)

Species Homo sapiens


The HRR pathway is an "error free" DNA repair mechanism that utilizes information encoded by homologous sequence to repair double-strand breaks (DSBs). HRR acts on DSBs occurring within replicated DNA (replication-independent DSBs) or on DSBs that are generated at broken replication forks (replication-dependent DSBs). Repair by homologous recombination involves processing of the ends of the DNA double-strand break, homologous DNA pairing and strand exchange, repair DNA synthesis, and resolution of the heteroduplex molecules.

Locations in the PathwayBrowser
Additional Information
Compartment nucleoplasm
GO Biological Process double-strand break repair via homologous recombination (0000724)