Reactome: A Curated Pathway Database

Formation of open bubble structure in DNA by helicases (R-HSA-73934)

Species Homo sapiens

Summation

Two DNA helicases XPG and XPD, which are part of TFIIH, unwind DNA duplex around this lesion to form an open bubble structure that exposes the damaged site.

Locations in the PathwayBrowser
Additional Information
Compartment nucleoplasm
GO Biological Process nucleotide-excision repair, DNA duplex unwinding (0000717)
Catalyst Activity
PhysicalEntity Activity Active Units
pre-incision complex in GG-NER helicase activity (0004386)