Reactome: A Curated Pathway Database

3'- incision of DNA by XPG in GG-NER (R-HSA-73938)

Species Homo sapiens


The cleavage of the damaged strand of DNA 3' to the site of damage occurs at the junction of single-stranded DNA and double-stranded DNA that is formed when the DNA duplex is unwound. The incision is carried out by XPG.

Locations in the PathwayBrowser
Additional Information
Compartment nucleoplasm
GO Biological Process nucleotide-excision repair, DNA incision, 3'-to lesion (0006295)
Catalyst Activity
PhysicalEntity Activity Active Units
incision complex for GG-NER endonuclease activity (0004519)
Literature References
pubMedId Title Journal Year
10214908 DNA damage recognition during nucleotide excision repair in mammalian cells. Biochimie 1999