Reactome: A Curated Pathway Database

5'-incision of DNA by ERCC1-XPF in GG-NER (R-HSA-73939)

Species Homo sapiens

Summation

The cleavage of the damaged strand of DNA 5' to the site of damage occurs at the junction of single-stranded DNA and double-stranded DNA that is formed when the DNA duplex is unwound. The incision is carried out by ERCC1-XPF complex.

Locations in the PathwayBrowser
Additional Information
Compartment nucleoplasm
GO Biological Process nucleotide-excision repair, DNA incision, 5'-to lesion (0006296)
Literature References
pubMedId Title Journal Year
10214908 DNA damage recognition during nucleotide excision repair in mammalian cells. Biochimie 1999