Reactome: A Curated Pathway Database

Dual incision reaction in GG-NER (R-HSA-73941)

Species Homo sapiens

Summation

Dual incision at defined positions flanking the DNA damage is carried out by XPG (3' -incision) and ERCC1-XPF (5'-incision) complex. The resulting excised fragment is ~27-30 bp long and contains the lesion.

Locations in the PathwayBrowser
Additional Information
Compartment nucleoplasm
GO Biological Process nucleotide-excision repair, DNA damage removal (0000718)
Literature References
pubMedId Title Journal Year
10583946 Quality control by DNA repair Science 1999