Reactome: A Curated Pathway Database
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CYLD deubiquitinates NEMO

Stable Identifier
R-HSA-741411
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

RIP2-induced ubiquitination of NEMO and consequent NFkappaB activation can be reversed in a dose-responsive manner by the deubiquitinase CYLD, suggesting that CYLD negatively regulates RIP2-induced NEMO ubiquitinylation.

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
Lys63-specific deubiquitinase activity of CYLD [cytosol] CYLD [cytosol] Lys63-specific deubiquitinase activity (0061578)
Orthologous Events