CYLD deubiquitinates NEMO (R-HSA-741411) [Homo sapiens]


RIP2-induced ubiquitination of NEMO and consequent NFkappaB activation can be reversed in a dose-responsive manner by the deubiquitinase CYLD, suggesting that CYLD negatively regulates RIP2-induced NEMO ubiquitinylation.

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Compartment cytosol
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Catalyst Activity
PhysicalEntity Activity Active Units
CYLD protein K63-linked deubiquitination (0070536)  
Literature References
pubMedId Title Journal Year
15620648 The Crohn's disease protein, NOD2, requires RIP2 in order to induce ubiquitinylation of a novel site on NEMO Curr Biol 2004
12917691 The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination Nature 2003
Inferred Entries
Orthologous events