Reactome: A Curated Pathway Database

CYLD deubiquitinates NEMO (R-HSA-741411) [Homo sapiens]

Reaction
Summation

RIP2-induced ubiquitination of NEMO and consequent NFkappaB activation can be reversed in a dose-responsive manner by the deubiquitinase CYLD, suggesting that CYLD negatively regulates RIP2-induced NEMO ubiquitinylation.

Additional Information
Compartment cytosol
Catalyst Activity
PhysicalEntity Activity Active Units
CYLD protein K63-linked deubiquitination (0070536)