CYLD deubiquitinates NEMO

Stable Identifier
R-HSA-741411
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

RIP2-induced ubiquitination of NEMO and consequent NFkappaB activation can be reversed in a dose-responsive manner by the deubiquitinase CYLD, suggesting that CYLD negatively regulates RIP2-induced NEMO ubiquitinylation.

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
Lys63-specific deubiquitinase activity of CYLD [cytosol]
Physical Entity
Activity
Orthologous Events